Alcohol

Vyvanse and Alcohol

Last updated:
July 15, 2025

It is not advisable to consume alcohol while taking Vyvanse, and prescribing doctors will warn against it.

Using Vyvanse (lisdexamfetamine) together with alcohol can increase the risk of cardiovascular side effects such as:

  • increased heart rate
  • chest pain
  • blood pressure changes

You should avoid or limit the use of alcohol while being treated with Vyvanse.

Combining Vyvanse and alcohol can produce other health complications like cardiomyopathy. 

Long-term use of Vyvanse can also increase the risk of cardiomyopathy, a heart muscle disease that makes it more difficult for your heart to pump blood throughout the body. Cardiomyopathy can lead to heart failure. Excess alcohol use can also cause high blood pressure and cardiomyopathy, as well.

Not only can mixing alcohol and Vyvanse increase the risk of developing cardiomyopathy, but the combination of the two is also riskier in those with pre-existing heart health conditions.

The risks of mixing alcohol and Vyvanse: Increased risk of addiction and overdose

Not only does Vyvanse addiction and alcohol present some immediate health risks, such as alcohol poisoning and heart problems, but it also has some real long-term health complications.

As Vyvanse is a stimulant and alcohol a depressant, the two can cancel out each other’s effects. This makes it more likely for you to drink more alcohol than you usually would, as it will take more for you to feel drunk whilst taking Vyvanse. You may also be tempted to take more.

Vyvanse overdose can be fatal. If you spot the signs in someone else or feel you have taken too much, contact your local emergency services immediately for help.

If you frequently abuse both together, you will be at a high risk of developing an alcohol and Vyvanse addiction (dual addiction) and of overdosing.

Dual addictions are not only more high risk in terms of mortality but are also more complex to treat. Alcohol addiction withdrawal symptoms can be life-threatening, especially when another substance is involved. However, recovery is completely possible with the right medical and therapeutic treatment.

Related topics

Addiction Assessment

Book a FREE Confidential Assessment at Your Nearest Rehab Centre

woman holding a prednisone bottle in her hand with the label showing
Prednisone and Alcohol

Rehabilitation from alcohol can be one of the most challenging addiction recovery journeys. Let us show you how to succeed.

Read more
drawing of a woman shaking inside a circle highlighting her
Delirium Tremens

Rehabilitation from alcohol can be one of the most challenging addiction recovery journeys. Let us show you how to succeed.

Read more
Man holding beer bottle and pills, depicting risky combination of alcohol and medications like naproxen|Medical illustration showing a cross-section of a healthy stomach alongside magnified views of healthy stomach lining and gastritis-affected lining, demonstrating the difference in tissue appearance|Infographic warning against mixing alcohol and naproxen (Aleve, Naprosyn, Flanax), explaining that alcohol is a depressant and naproxen is an NSAID|Person clutching stomach in pain with highlighted digestive system, illustrating potential gastrointestinal effects of combining naproxen and alcohol
Naproxen and Alcohol

Rehabilitation from alcohol can be one of the most challenging addiction recovery journeys. Let us show you how to succeed.

Read more
A man looking contemplative, leaning against a window, symbolizing introspection during addiction recovery.|Close-up of a clock face with the words "Time to Sober Up" instead of numbers, emphasizing the importance of taking action for sobriety
Medicine for Alcohol Withdrawal: Uses, Benefits, and Risks

Rehabilitation from alcohol can be one of the most challenging addiction recovery journeys. Let us show you how to succeed.

Read more

Ready to start?
We're here for you